Objective To evaluate the application value of general anesthesia combined with iliac fascia nerve block in total hip arthroplasty. Methods A total of 80 patients who underwent elective total hip arthroplasty from January 2022 to December 2023 were selected as study subjects, and randomly divided into an observation group （40 cases, general anesthesia combined with iliac fascia nerve block） and a control group （40 cases, general anesthesia）, and the efficacy of the two groups was compared. Results The pain scores of the observation group at 2, 6, 12 and 24 h postoperaitvely were significantly lower than those of the control group （P<0.05）. Before anesthesia, the hemodynamic indexes of the two groups were not statistically different （P>0.05）. At the time of intubation, 30 min after operation, and at the time of extubation, the hemodynamic variations of the observation group were significantly lower than those of the control group （P<0.05）. The incidence of adverse reactions between the two groups were not different （P>0.05）. Conclusion The application of general anesthesia combined with iliac fascia nerve block in total hip arthroplasty can achieve stable hemodynamic indexes while not increase adverse reactions.