Objective To study the efficacy of retrograde intrarenal surgery （RIRS） combined with front flexible negative pressure suction sheath in the treatment of upper urinary tract calculi. Methods A total of 60 patients with upper urinary tract calculi admitted to our hospital from May 2024 to April 2025 were randomly divided into an observation group and a control group according to random number table method, with 30 cases in each group. The control group was treated with RIRS combined with ordinary flexible ureteroscope sheath, and the observation group was treated with RIRS combined with front flexible negative pressure suction sheath. The stone clearance rate, pain degree [visual analogue scale （VAS） score], inflammatory indicators [white blood cell count （WBC） and high-sensitivity C-reactive protein （hs-CRP）], stress indicators [epinephrine （E） and norepinephrine （NE）], and complication incidence were compared between the two groups. Results The observation group showed a significantly higher stone clearance rate than the control group （P<0.05）. There was no significant difference in VAS score between the two groups before surgery （P>0.05）, but the postoperative VAS score in the observation group [（4.26±1.26） points] was significantly lower than that in the control group [（6.36±1.51） points; t=5.849, P<0.05]. No significant differences were observed in WBC and hs-CRP levels between the two groups before surgery （P>0.05）, but the improvement of WBC and hs-CRP levels in the observation group was significantly larger than that in the control group （P<0.05）. No significant differences were observed in stress indicators between the two groups before surgery （P>0.05）, but the postoperative stress hormone level in the observation group was significantly lower than that in the control group （P<0.05）. The complication incidence in the observation group was significantly lower than that in the control group （P<0.05）. Conclusion RIRS combined with front front flexible negative pressure suction sheath in the treatment of upper urinary tract calculi has significant advantages in improving stone clearance rate, allevating postoperative pain, and reducing postoperative inflammation, stress response, and complications, which is worthy of promoting in clinical practice.
YANG Dahong
,
GONG Hanzhong
,
WANG Li
. Clinical efficacy and short-term postoperative complications of RIRS combined with front flexible negative pressure suction sheath in treatment of upper urinary tract stones[J]. Surgical Research and New Technique, 2026
, 15(1)
: 39
-42
.
DOI: 10.3969/j.issn.2095-378X.2026.01.009
[1] 庄承霖,庄宝钧,吕继宗,等.头端可弯曲负压吸引鞘、常规鞘输尿管软镜手术与经皮肾镜治疗>2 cm上尿路结石的疗效比较[J].现代泌尿外科杂志,2024,29(10):875-879.
[2] 林建峰,吴德柱.可弯曲负压吸引鞘联合经皮肾通道输尿管软镜钬激光碎石术治疗复杂性肾结石的疗效观察及对患者肾脏血流动力学的影响[J].哈尔滨医药,2025,45(1):65-67.
[3] 兰海河,夏勇,邵林海,等.输尿管软镜钬激光碎石术联合微通道经皮肾镜取石术对上尿路结石患者的治疗效果分析[J].中国药物与临床,2021,21(16):2809-2811.
[4] Chen Y, Li C, Gao L, et al.Novel flexible vacuum-assisted ureteral access sheath can actively control intrarenal pressure and obtain a complete stone-free status[J]. J Endourol, 2022,36(9): 1143-1148.
[5] 钟文,曾国华. 国际尿石症联盟输尿管软镜碎石术指南解读[J]. 临床泌尿外科杂志,2023,38(1):1-4.
[6] 顾燕青,郭宗保,唐新宇,等.输尿管软镜联合可弯曲负压吸引鞘用于感染性肾结石取石术的倾向评分匹配分析[J].中国内镜杂志,2025,31(2):1-8.
[7] 唐庆来,王杜渐,柳发德,等.可弯曲负压吸引鞘联合一次性输尿管软镜碎石术治疗2~3 cm上尿路结石的疗效[J].现代泌尿外科杂志,2024,29(10):859-864.
[8] Yue G, Dou S, Cai C, et al.A novel distal active flexible vacuum-assisted ureteric access sheath in retrograde intrarenal surgery[J]. Urology, 2023, 179(9): 204-205.
[9] 罗靖,龙家才,李昕,等.输尿管软镜碎石术与微通道经皮肾镜碎石术治疗2~3 cm上尿路结石的有效性和安全性[J].现代泌尿外科杂志,2022,27(3):242-245.
[10] 梁浩,冯振华,彭业平,等.可控负压吸引下输尿管软镜钬激光碎石术治疗肾结石合并尿路感染的疗效分析[J].中国实用医药,2024,19(2):46-49.
