Objective To summarize clinic experience of laparoscopy,choledochoscopy and duodenoscopy for treatment of extrahepatic bile duct stones and stenosis of papillory with primary closure of bile duct incision during the course of laparoscopy.Methods To accomplish LC and common bile duct exploration firstly,through ureteric catheter and zebra guidewire of common bile duct incision into duodenum,through duodenoscopy via oral into the papillary of duodenum,these approaches were used to cut through the stenosis of papillory for electro-knife by pin-head-like .It was received the primary closure of duct incision.Results It was successful in 199 cases removing the gallbladder and the common bile duct stones.Papillotomy was successful in 197 with primary closure of bile duct incision out of 199 cases,two cases were shifted to T tube drainage.Three patients suffered from a slight pancreatitis.Bile leakage of primary closure of duct incision was cured by patent drainage in 4 cases.perforation of intestine and bile duct,bleeding,severe pancreatitis and death were found in all of the patients.Conclusion If patients are suitable,LEST with primary closure of bile duct incision is safe and effective.