Objective To evaluated feasibility and safety of a new type of aortic valved stent in transcatheter aortic valve implantation (TAVI) using retrograde approach by testing and animal implantation in vitro.Methods Firstly,a new type of aortic valve stent sutured with porcine pericardium valves was made.The fluid passing test,expanding and releasing tests,static and releasing tests in tube were peformed in vitro for all stents.Then,the stents were implanted in six pigs using retrograde approach.These pigs were euthanized 12 h after implantation for anatomic evaluation.Results In vitro the tests showed that closure of new type of aortic valved stent leaflets were effective,and stents could be released through catheter,then expanded completely and could fix fast in tube.Left and right coronary artery flow rates did not change significantly when the stents were released above valve leaflets (P=0.7426,P=0.1487) after implantation.In vivo experiments indicated that TAVI was successfully performed in six pigs using retrograde approach.However,one pig died 10h after implantation because stents were not expanded completely.The leaflets in stents opened well and no valvular regurgitation was observed in the rest five pigs.And no thrombosis was found.Conclusion The new type of aortic valved stent designed in this study was characterised with good stability and could avoid the impact caused by valve leaflets on the coronary artery.
CAI Jian-zhi
,
ZHOU Yong-xin
,
SHAO Jie
,
MEI Yun-qing
,
WANG Yong-wu
. Aortic valved stent designed without influence on coronary artery[J]. Surgical Research and New Technique, 2013
, 2(4)
: 232
-239
.
DOI: 10.3969/j.issn.2095-378X.2013.04.006
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