[1] 徐万鹏.骨科肿瘤学[M].2版.北京:人民军医出版社,2008:6-7.
[2] Ferrari S,Smeland S,Mercuri M,et al.Neoadjuvant chemotherapy with high-dose Ifosfamide,high-dose methotrexate,cisplatin,and doxorubicin for patients with localized osteosarcoma of the extremity:a joint study by the Italian and Scandinavian Sarcoma Groups[J].J Clin Oncol,2005,23(34):8845-8852.
[3] Wittig JC,Bickels J,Priebat D,et al.Osteosarcoma:a multidisciplinary approach to diagnosis and treatment[J].Am Fam Physician,2002,65(6):1123-1132.
[4] Kang Q,Sun MH,Cheng H,et al.Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery[J].Gene Ther,2004,11(17):1312-1320.
[5] Martelli L,Di MF,Botti P,et al.Accumulation,platinum-DNA adduct formation and cytotoxicity of cisplatin,oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines,characterized by p53 wild-type status[J].Biochem Pharmacol,2007,74(1):20-27.
[6] Hoang BH.Wnt,osteosarcoma,and future therapy[J].J Am Acad Orthop Surg,2012,20(1):58-59.
[7] McQueen P,Ghaffar S,Guo Y,et al.The Wnt signaling pathway:implications for therapy in osteosarcoma[J].Expert Rev Anticancer Ther,2011,11(8):1223-1232.
[8] Modder UI,Oursler MJ,Khosla S,et al.Wnt10b activates the Wnt,notch,and NFkappaB pathways in U2OS osteosarcoma cells[J].J Cell Biochem,2011,112(5):1392-1402.
[9] Dieudonne FX,Marion A,Hay E,et al.High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells[J].Cancer Res,2010,70(13):5399-5408.
[10] Rubin EM,Guo Y,Tu K,et al.Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma[J].Mol Cancer Ther,2010,9(3):731-741.
[11] Cai Y,Mohseny AB,Karperien M,et al.Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma[J].J Pathol,2010,220(1):24-33.
[12] Zhang P,Yang Y,Nolo R,et al.Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness[J].Oncogene,2010,29(20):2916-2926.
[13] Tanaka M,Setoguchi T,Hirotsu M,et al.Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation[J].Br J Cancer,2009,100(12):1957-1965.
[14] Engin F,Bertin T,Ma O,et al.Notch signaling contributes to the pathogenesis of human osteosarcomas[J].Hum Mol Genet,2009,18(8):1464-1470.
[15] Warzecha J,Dinges D,Kaszap B,et al.Effect of the Hedgehog-inhibitor cyclopamine on mice with osteosarcoma pulmonary metastases[J].Int J Mol Med,2012,29(3):423-427.
[16] Nagao H,Ijiri K,Hirotsu M,et al.Role of GLI2 in the growth of human osteosarcoma[J].J Pathol,2011,224(2):169-179.
[17] Zhang G,Li M,Zhu X,et al.Knockdown of akt sensitizes osteosarcoma cells to apoptosis induced by Cisplatin treatment[J].Int J Mol Sci,2011,12(5):2994-3005.
[18] Zhang B,Shi ZL,Liu B,et al.Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma:the role of Akt and nuclear factor-kappaB[J].Anticancer Drugs,2010,21(3):288-296.
[19] Xie X,Yin J,Jia Q,et al.Quercetin induces apoptosis in the methotrexate-resistant osteosarcoma cell line U2-OS/MTX300 via mitochondrial dysfunction and dephosphorylation of Akt[J].Oncol Rep,2011,26(3):687-693.
[20] Yu Y,Luk F,Yang JL,et al.Ras/Raf/MEK/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model[J].Anticancer Res,2011,31(4):1147-1152.
[21] Tsubaki M,Yamazoe Y,Yanae M,et al.Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF,HGF,and TGF-beta as angiogenic factors in mouse osteosarcoma[J].Cytokine,2011,54(1):100-107.
[22] Geryk-Hall M,Yang Y,Hughes DP.Driven to death:inhibition of farnesylation increases Ras activity in osteosarcoma and promotes growth arrest and cell death[J].Mol Cancer Ther,2010,9(5):1111-1119.
[23] Tomonaga M,Hashimoto N,Tokunaga F,et al.Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells[J].Int J Oncol,2012,40(2):409-417.
[24] Nishimura A,Akeda K,Matsubara T,et al.Transfection of NF-kappaB decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma[J].Cancer Gene Ther,2011,18(4):250-259.
[25] Chicheportiche Y,Bourdon PR,Xu H,et al.TWEAK,a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis[J].J Biol Chem,1997,272(51):32401-32410.
[26] Hansson GK.Inflammation,atherosclerosis,and coronary artery disease[J].N Engl J Med,2005,352(16):1685-1695.
[27] Feng SL,Guo Y,Factor VM,et al.The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas[J].Am J Pathol,2000,156(4):1253-1261.
[28] Winkles JA,Tran NL,Brown SA,et al.Role of TWEAK and Fn14 in tumor biology[J].Front Biosci,2007,12:2761-2771.
[29] Schapira K,Burkly LC,Zheng TS,et al.Fn14-Fc fusion protein regulates atherosclerosis in ApoE-/-mice and inhibits macrophage lipid uptake in vitro[J].Arterioscler Thromb Vasc Biol,2009,29(12):2021-2027.
[30] Sugito T,Mineshiba F,Zheng C,et al.Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation[J].Oral Dis,2009,15(1):76-81.
[31] Haile WB,Echeverry R,Wu J,et al.The interaction between tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 promotes the recruitment of neutrophils into the ischemic brain[J].J Cereb Blood Flow Metab,2010,30(6):1147-1156.
[32] Yanaba K,Yoshizaki A,Muroi E,et al.Elevated circulating TWEAK levels in systemic sclerosis:association with lower frequency of pulmonary fibrosis[J].J Rheumatol,2009,36(8):1657-1662.
[33] Ando T,Ichikawa J,Wako M,et al.TWEAK/Fn14 interaction regulates RANTES production,BMP-2-induced differentiation,and RANKL expression in mouse osteoblastic MC3T3-E1 cells[J].Arthritis Res Ther,2006,8(5):R146.
[34] Polek TC,Talpaz M,Darnay BG,et al.TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR.Evidence for a second TWEAK receptor[J].J Biol Chem,2003,278(34):32317-3223.
[35] Lynch CN,Wang YC,Lund JK,et al.TWEAK induces angiogenesis and proliferation of endothelial cells[J].J Biol Chem,1999,274(13):8455-8459.
[36] Jakubowski A,Browning B,Lukashev M,et al.Dual role for TWEAK in angiogenic regulation[J].J Cell Sci,2002,115(2):267-274.
[37] Donohue PJ,Richards CM,Brown SA,et al.TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity[J].Arterioscler Thromb Vasc Biol,2003,23(4):594-600.
[38] Tran NL,McDonough WS,Donohue PJ,et al.The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors[J].Am J Pathol,2003,162(4):1313-1321.
[39] Pradet-Balade B,Medema JP,Lopez-Fraga M,et al.An endogenous hybrid mRNA encodes TWE-PRIL,a functional cell surface TWEAK-APRIL fusion protein[J].EMBO J,2002,21(21):5711-5720.
[40] Kawakita T,Shiraki K,Yamanaka Y,et al.Functional expression of TWEAK in human hepatocellular carcinoma:possible implication in cell proliferation and tumor angiogenesis[J].Biochem Biophys Res Commun,2004,318(3):726-733.
[41] Ho DH,Vu H,Brown SA,et al.Soluble tumor necrosis factor-like weak inducer of apoptosis overexpression in HEK293 cells promotes tumor growth and angiogenesis in athymic nude mice[J].Cancer Res,2004,64(24):8968-8972.
[42] Michaelson JS,Cho S,Browning B,et al.Tweak induces mammary epithelial branching morphogenesis[J].Oncogene,2005,24(16):2613-2624.
[43] Kawakita T,Shiraki K,Yamanaka Y,et al.Functional expression of TWEAK in human colonic adenocarcinoma cells[J].Int J Oncol,2005,26(1):87-93.
[44] Jakubowski A,Ambrose C,Parr M,et al.TWEAK induces liver progenitor cell proliferation[J].J Clin Invest,2005,115(9):2330-2340.
[45] Nakayama M,Ishidoh K,Kayagaki N,et al.Multiple pathways of TWEAK-induced cell death[J].J Immunol,2002,168(2):734-743.
[46] Lin BR,Huang MT,Chen ST,et al.Prognostic Significance of TWEAK Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion[J].Ann Surg Oncol,2011,19(3):385-394.
[47] Campbell S,Burkly LC,Gao HX,et al.Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells[J].J Immunol,2006,176(3):1889-1898.
[48] Zhou H,Marks JW,Hittelman WN,et al.Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells[J].Mol Cancer Ther,2011,10(7):1276-1288.
