Objective To improve the life quality of patients with hemorrhoids through assessing the effectiveness of hardener injection combined with automatic ligation of hemorrhoids in the treatment of hemorrhoids.Methods A total of 126 patients with hemorrhoids admitted to People’s Hospital of Luhe County in Shanwei City of Guangdong Province from March 2015 to January 2017 were enrolled as study subjects and randomly divided into a general group (even number) and an observation group (odd number) according to the last digit of visit number,with 63 cases in each group.The general group was treated with automatic ligation of hemorrhoids,and the observation group received hardener injection additionally.Postoperative recovery and postoperative complications were compared between patients with different operations.Results Less hematochezia,pain,and hospitalization time were observed in the observation group than in the general group (P<0.05),and there was no significant difference regarding the improvement of haemorrhoids reduction between the two groups (P>0.05).The rates of postoperative dysuresia and secondary bleeding were 3.2% and 0% in the observation group,which were significantly lower than 11.1% and 4.8% of the general group,and postoperative complications were fewer in the observation group (P<0.05).Conclusion Clinical treatment for patients with hemorrhoids using hardener injection combined with automatic ligation of hemorrhoids could result in low postoperative bleeding rate,fast recovery,and good treatment effect.