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Review

Effect and treatment of blood-material-interface interaction during extracorporeal membrane oxygenation

  • WANG Yuliang ,
  • WANG Qi ,
  • ZHANG Yangyang
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  • 1.Department of Hygiene Analysis and Detection,School of Public Health,Nanjing Medical University, Nanjing 211100,China;
    2.The Fourth School of Clinical Medicine,Nanjing Medical University,Nanjing 211100,China;
    3.Department of Cardiovascular Surgery,East Hospital Affiliated to Tongji University, Shanghai 200102,China

Received date: 2017-04-03

  Online published: 2017-07-21

Abstract

Extracorporeal membrane oxygenation (ECMO) is a sustainable technique with gas exchange and circulation support.It is extensively used in patients who are so severe that need cardiopulmonary support.Blood-material-interface interaction (BMII) during ECMO initiates adsorption between plasma proteins and material surface,activates blood coagulation pathway,and leads to coagulopathy and complications such as bleeding and thrombosis.Systematic application of anticoagulant drugs,anti-fouling coating on material surface,and anti-clotting drug release coating can partially relieve and solve the problem of BMII.Raising new concepts and developing new techniques will help reduce BMII and improve the therapentic effects of ECMO.

Cite this article

WANG Yuliang , WANG Qi , ZHANG Yangyang . Effect and treatment of blood-material-interface interaction during extracorporeal membrane oxygenation[J]. Surgical Research and New Technique, 2017 , 6(2) : 113 -117 . DOI: 10.3969/j.issn.2095-378X.2017.02.013

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