Objective To analyze the effect of lumbar plexus combined with sciatic nerve block anesthesia on blood pressure, heart rate, adverse reaction, and prognosis in elderly patients with femoral neck fracture.Methods A total of 100 elderly patients who underwent femoral neck fracture surgery in our hospital from February 2016 to August 2018 were randomly selected as the study subjects and divided into study group and control group, with 50 cases in each group.The control group was given combined spinal-epidural anesthesia, and the study group was given combined lumbar plexus and sciatic nerve block anesthesia.The heart rate and blood pressure were compared between the two groups.Results The heart rate, diastolic blood pressure, and systolic blood pressure before and after anesthesia in the control group were not significantly different from those in the study group.The incidence rate of adverse reactions such as headache, nausea, and vomiting in the control group was 12.00%, higher but not statistically than that in the study group (4.00%)(P>0.05).The blood loss volume, blood transfusion volume, and fracture healing time in the control group were significantly higher than those in the study group (P<0.05).Conclusion The application of lumbar plexus combined with sciatic nerve block anesthesia in elderly patients with femoral neck fracture can effectively induce stable blood pressure and heart rate, reduce intraoperative blood transfusion, shorten fracture healing time, and improve the safety of treatment, which is worthy of popularization and application.