Objective To explore the effect of transurethral bipolar plasmakinetic resection of prostate (TUPKRP) on patients with benign prostatic hyperplasia.Methods A group of 50 patients with benign prostatic hyperplasia treated with TUPKRP from January 2017 to April 2018 were selected as observation group,and another group of 50 patients with benign prostatic hyperplasia treated with transurethral resection of prostate (TURP) at same period were selected as control group.The therapeutic effects were compared between two groups.Results The difference in total effective rate between the two groups was not statistically significant (P>0.05),nor were the differences in the time of washing bladder,removed gland weight,IPSS,RU,and Q_max (P>0.05).The surgery time,blood loss volume during surgery,QoL,IIEF-5 score,and complication rate in the observation group were significantly better than those in the control group (P<0.05).Conclusion TUPKRP applied to benign prostatic hyperplasia could reduce intraoperatve blood loss,reduce the incidence of complications,ensure curative effect,improve the quality of life and sexual function of patients,and therefore it is worthy of clinical application.