Objective To investigate the effect of endoscopic hemostasis on acute non-varicose upper gastrointestinal bleeding and its symptomatic nursing.Methods Based on the etiology and endoscopic improved Forrest classification,173 cases of acute non-varicose upper gastrointestinal bleeding received different treatments,including injection of drugs,argon ion coagulation (APC),vascular clamp,and combined hemostatic therapy.Their curative effects and symptomatic nursing were observed.Results In the 173 patients with non-varicose upper gastrointestinal bleeding,the total immediate hemostasis rate was 98.27% (170/173),and the rebleeding rate was 8.09% (14/173).Among them,69 patients in the injection group had the immediate hemostasis rate of 92.75% (64/69),effective hemostasis rate of 85.51% (59/69),rebleeding rate of 11.59%(8/69),and surgical operation rate of 10.14% (7/69); 8 cases in the APC group had the immediate hemostasis rate of 87.50% (7/8),effective hemostasis rate of 75.00% (6/8),and rebleeding rate of 25.00%(2/8); 91 patients in the vascular clamp group had the immediate hemostasis rate of 100% (91/91),effective hemostasis rate of 96.70% (88/91),rebleeding rate of 3.30% (3/91),which was significantly lower than those of the injection group and the APC group (P<0.05),and surgical operation rate of 2.2% (2/91); 5 patients in the combined group showed the immediate hemostasis rate of 100% (5/5),effective hemostasis rate of 80.00%(4/5),rebleeding rate of 20.00%(1/5),and surgical operation rate of 20.00%(1/5).Neither significant complications nor deaths occurred.Conclusion Endoscopic hemostasis exhibits a quick and precise effect; therefore,it should be the preferred first-aid treatment for acute non-varicose upper gastrointestinal bleeding patients.The key to successful rescue of the disease includes accurate assessment,fast recovery of effective circulation,endoscopic hemostatic treatment appropriate for bleeding etiologies,and close cooperation between doctors and nurses.