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Review

Research progress on siRNA interference techniquein drug-resistant ovarian cancer

  • LI Xia ,
  • TONG Xiaowen
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  • 1.Tongji University School of Medicine, Shanghai 200092, China;
    2.Department of Obstetrics and Gynaecology, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China

Received date: 2018-04-09

  Online published: 2019-12-10

Abstract

Ovarian cancer has the highest mortality rate among female reproductive cancer.Because it has no special clinical manifestation in early stage, and the majority of patients are diagnosed in advanced stage.This is a disease with a propensity to recur or deteriorate despite dramatic responses to the treatment of a combination of cytoreductive surgery and platinum-based chemotherapy.RNA interference is a sequence-specific posttranscriptional gene silencing triggered by double-stranded RNA, in which small interfering RNA plays a core role.This paper reviewed the research progress on small interfering RNA technical principle, delivery, and its application in drug-resistant ovarian cancer in recent five years.

Cite this article

LI Xia , TONG Xiaowen . Research progress on siRNA interference techniquein drug-resistant ovarian cancer[J]. Surgical Research and New Technique, 2018 , 7(2) : 127 -131 . DOI: 10.3969/j.issn.2095-378X.2018.02.013

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