Objective To investigate the influence of different postures on the patients administered with compound anisodine injection in temporal region.Methods A total of 97 patients who required continuous temporal subcutaneous injection of compound anisodine for 14 days were randomly divided into a sitting group (injected with sitting posture,48 cases) and a lying group (injected with supine posture,head to healthy side,49 cases).The two groups of patients were compared in pain,negative emotion degree,adverse reaction rate,and satisfaction after first injection.Results The lying group showed remarkably lower pain level,negative emotion degree,and adverse reaction rate,and higher satisfaction than the sitting group.Conclusion In temporal subcutaneous injection of compound anisodine,using supine posture can reduce patients’ pain,adverse reaction rate,and the incidence of negative emotion,as well as improve patients’ compliance and satisfaction.