Objective To evaluate the effect of painless treatment in perioperative period of anorectal surgery.Methods A total of 200 patients with anorectal surgery were randomly divided into an experimental group and a control group.The experimental group (n=100) was treated with painless multimodal analgesia.The control group (n=100) was treated with oral celecoxib or intramuscular tramadol.The pain scores of postoperative 6 h,24 h,48 h,5 d,and first defecation,as well as the satisfaction score,of the two groups were compared.Results The pain score of postoperative 6 h of the experimental group was (3.6±0.6),and that of the control group was (3.7±0.3),showing no statistical difference (P>0.05).The pain scores of postoperative 24 h (2.7±0.9),48 h (4.3±0.4),5 d (3.1±0.6),and first defecation (5.7±1.5) of the experimental group were lower than those of the control group [(5.9±0.2),(5.6±1.3),(6.3±0.4),and (8.9±1.5),respectively],and the difference was statistically significant (P<0.05).The satisfaction score of the experimental group (4.6±0.3) was higher than that of the control group (3.4±0.6)(P<0.05).Conclusion Painless treatment for perioperative anorectal patients using multimodal analgesia can effectively reduce postoperative pain and improve quality of life.