Stem cells have the potential for self-renewal and multi-directional differentiation.Experiments have proven that stem cells can differentiate into hepatocyte-like cells under certain conditions,with hepatocyte markers and functions.Liver transplantation is the only effective and curative way for end-stage liver disease,but is limited by a shortage of donor organs,high costs of surgery,long-term immune therapy,and so on.In light of that,stem cells are of potential application value in the treatment of end-stage liver disease.This review focused on the regulatory mechanisms of stem cells differentiated into hepatocyte-like cells.
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