Objective To investigate the difference of curative effect between electro-resection and electro-fulguration on female cystitis glandularis.Methods Female glandular cystitis patients who were hospitalized in Suzhou Jiulong Hospital were selected, including 42 patients undergoing transurethral electro-fulguration (control group) and 70 patients undergoing transurethral electro-resection (observation group).Postoperative follow-up data and differences in efficacy were compared.Results There were no significant differences in the operation time, intraoperative blood loss, hospital stay, and indwelling catheter time between the two groups (P>0.05).The number of urination and urinary urgency at 24 h after operation were lower than those before operation (P<0.05), and the number of urination and urinary urgency were lower in the observation group than those in the control group at 24 h after operation (P<0.05).There was no significant difference in the total effective rate between the two groups (P>0.05).However, the postoperative cure rate of the observation group was significantly higher than that of the control group (P<0.05).In the electro-fulguration group, the symptom remission rate was higher than that in the electro-resection group within 1 month after surgery.However, the total remission rate of the resection group was higher in the electro-fulguration group (P<0.05).There were no significant differences in the levels of Survivin and P53 between the two groups before operation.The postoperative positive rate in each group was lower than that before surgery (P<0.05).The levels of Survivin and P53 in the observation group were lower than those in the control group (P<0.05).Conclusion For female cystitis glandularis, transurethral electro-resection is better and worthy of further clinical promotion.