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Review

Research advance on miR-146a in coronary atherosclerotic heart disease

  • HUANG Haitao ,
  • ZHONG Chongjun
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  • Department of Cardiovascular Surgery, The First People’s Hospital of Nantong, Nantong 226001, China

Received date: 2018-09-12

  Online published: 2019-12-16

Abstract

The incidence of coronary atherosclerotic heart disease (CHD) is increasing in China, which can lead to serious and fatal complications such as myocardial infarction, heart failure, and sudden death.MiR-146a is closely related to the occurrence, development, and prognosis of CHD.It is expressed in endothelial cells, smooth muscle cells, and myocardiocytes of CHD animal models.It mainly regulates inflammatory immune response and angiogenesis by acting on related target genes and signaling pathways.MiR-146a can affect the risk factors of coronary heart disease, atherosclerotic plaque,coronary collateral circulation, ischemia-reperfusion injury, drug treatment, and so on.It can become a new target for the diagnosis and treatment of CHD.This article elaborated the relationship between miR-146a and CHD, aiming to provide a theoretical basis for clinical diagnosis, treatment, and efficacy evaluation of CHD.

Cite this article

HUANG Haitao , ZHONG Chongjun . Research advance on miR-146a in coronary atherosclerotic heart disease[J]. Surgical Research and New Technique, 2018 , 7(3) : 201 -205 . DOI: 10.3969/j.issn.2095-378X.2018.03.014

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