Objective To provide reference for the development of individualized treatment regime for axillary lymph node by analyzing sentinel lymph node (SLN) and selected clinical and pathological characteristics of that may affect non-sentinel lymph node (NSLN) metastasis during early breast cancer. Methods The clinical and pathological data of early breast cancer patients with sentinel lymph node biopsy (SLNB) positive and who further received axillary lymph node dissection (ALND) in the Second Affiliated Hospital of Xiamen Medical College from March 2015 to December 2018 were retrospectively analyzed. Univariate analysis and multiple logistic regression analysis were applied to analyze the relationships between these clinicopathological factors and NSLN metastasis. Results According to the inclusion and exclusion criteria, a total of 98 cases were enrolled in the study. Among them, 33 (33.7%) patients had NSLN metastasis. The results of univariate analysis showed that histological grade (P=0.021), ≥3 positive SLN metastasis (P=0.013), and lymph-vascular invasion (P<0.001) were associated with NSLN metastasis. The results of multiple logistic analysis revealed that lymph-vascular invasion was an independent predictor for NSLN metastasis. Conclusion Histological grade, the number of positive SLN, and lymph-vascular invasion are correlated with NSLN metastasis. Lymph-vascular invasion may be an important independent predictor for NSLN metastasis.
WU Songling
,
ZHANG Meize
,
LIU Jiahui
,
ZHAN Qiaohui
. Factors of non-sentinel lymph node metastasis in 98 early breast cancer patients[J]. Surgical Research and New Technique, 2020
, 9(1)
: 6
-9
.
DOI: 10.3969/j.issn.2095-378X.2020.01.002
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