Objective To evaluate the effect of Ruiyun procedure for hemorrhoid (RPH) plus Diosmin on mixed hemorrhoid. Methods Eighty mixed hemorrhoid patients treated from January 2019 to September 2019 in our hospital were assigned to a regular surgery group and a combined surgery group (regular surgery combinded with RPH) by stratified sampling method, with 40 cases in each group. The curative effects were probed in the two groups. Results The total effective rate in the combined surgery group (92.5%) was significantly higher than that in the regular surgery group (P<0.05). Before treatment, the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) levels between the two groups were not significantly different (P>0.05); after treatment, the levels of above inflammatory factors in the two groups were remarkably reduced than before (P<0.05), and the levels in the combined surgery group were lower then those in the regular surgery gronp (P<0.05). The complication rate in the combined surgery group (7.5%) was significantly lower than that in the regular surgery group (25%)(P<0.05). Conclusion RPH combined with Diosmin applied for mixed hemorrhoid can obviously improve treatment effects by alleviating clinical symptoms and reducing the levels of inflammatory factors and inflammatory responses.