Objective To explore the application of Mulligan mobilisations with movement plus muscle energy techniques to cervical spondylotic radiculopathy (CSR). Methods A total of 86 CSR patients treated from February 2017 to February 2020 in our hospital were randomly assigned to two groups, with 43 cases in each group. The conventional group took conventional rehabilitation; the combined group took Mulligan mobilisations with movement and muscle energy techniques. Clinical assessment scale for cervical spondylosis (CASCS) scores, neck disability index (NDI) scores, active range of motion (AROM), Short-form 36 Health Survey Questionnaire (SF-36) scores, Visual Analogue Scale (VAS) scores, and muscle pressure pain threshold were compared before and after the treatment. Results The CASCS score, AROM, and SF-36 score were significantly higher and the NDI score and VAS score were significantly lower in the combined group than those in the conventional group (P<0.05). The pressure pain thresholds of trapezius, levator scapulae, and suboital muscles in the combined group were significantly lower than those in the conventional group (P<0.05). Conclusion Mulligan mobilisations with movement plus muscle energy techniques can relieve the clinical symptoms of cervical spondylosis, such as reducing neck disability, increasing the active range of motion, and reducing pain, and thereby improve the quality of life of patients.