Objective To evaluate the influences of different local regional recurrence （LRR） on prognosis of breast cancer patients after surgery. Methods The clinical data of 96 patients with breast cancer who received surgical treatment in the departments of breast surgery of the First Affiliated Hospital of Nanchang University and of Shanghai Wusong Hospital from January 2010 to December 2016 were analyzed retrospectively. According to the location of LRR, the patients were divided into three groups： ipilateral breast tumor recurrence （IBTR） group （n=33）, chestwall recurrence （CR） group （n=35）, and regional lymph node recurrence （LNR） group （n=28）. The clinical efficacy and overall survival （OS） of the two groups were compared, and the factors affecting the prognosis of LRR patients were analyzed by logistic regression. Results The objective remission rate of the CR group was 28.57%, significantly lower than that of the ITBR group （54.55%, P<0.05）. There were significant differences between the death group and the survival group in terms of pathological type, pathological stage, LRR, lymphatic metastasis, treatment mode （surgery, chemotherapy, and radiotherapy） after recurrence, and the expressions of ER, PR, and HER-2 （P<0.05）. Multiple logistic regression analysis results showed that pathological stage, HER-2 （positive）, and LRR （CR） were independent risk factors for prognosis of LRR patients with local recurrence after breast cancer surgery （P<0.05）, while surgery after LRR was an independent protective factor for prognosis （P<0.05）. Kaplan-Meier survival curve analysis results showed that the median OS of patients with different LRR locations from high to low were 50.76 months in the ITBR group （95% CI： 46.91-54.61）, 41.58 months in the LNR group （95% CI： 37.81-45.34）, and 33.28 months in the CR group （95% CI： 29.84-36.71） （χ²=15.10, P<0.05）. Conclusion LRR locations of postoperative breast cancer are closely related to prognosis, and ITBR shows a better therapeutic effect and prognosis. Active surgical resection of recurrent lesions is of great significance to prolong survival and improve prognosis of breast cancer patients with LRR.