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The origin of carcinoma-associated fibroblasts and its molecular mechanisms

  • ZHANG Hui ,
  • FAN Yue-zu ,
  • WANG Jin-si ,
  • LIN Meng-bo
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  • 1.Department of Surgical Oncology,Fujian Provincial Hospital,Fuzhou 35001,China;
    2.Department of Surgery,Tongji Hospital,Tongji University School of Medicine, Shanghai 200065,China

Online published: 2014-01-25

Abstract

Carcinoma-associated fibroblasts (CAFs) have not only been showed to play a crucial role in growth,progression and metastasis of tumors but also in the deposition of extracellular matrix (ECM).The normal fibroblasts,epithelial cells,endothelial cells and mesenchymal stem cells (MSCs) are recognized as the main source of CAFs.This paper aims to review the recent advances at the origin of the CAFs and its molecular mechanisms and possibility as potential therapeutic targets.

Cite this article

ZHANG Hui , FAN Yue-zu , WANG Jin-si , LIN Meng-bo . The origin of carcinoma-associated fibroblasts and its molecular mechanisms[J]. Surgical Research and New Technique, 2014 , 3(1) : 1 -7 . DOI: 10.3969/j.issn.2095-378X.2014.01.001

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