Objective To observe the expression of S100A7 in intrahepatic cholangiocarcinoma （ICC） and its clinical significance. Methods Tissue specimens from 30 cases of pathologically proven ICC were collected in the Eastern Hepatobiliary Surgery Hospital from January 2018 to January 2020. The expression of S100A7 in ICC tissue was analyzed by immunohistochemistry, Western blotting and PCR. Results The S100A7 level expressed in ICC tissue was significantly higher than that in para-carcinoma （50% vs. 10%, P<0.05）.The expression of S100A7 was correlated with the depth of tumor invasion, lymph node metastasis and TNM stage （all P<0.05）, but not correlated with the patient's sex, age, lymphatic invasion, tumor differentiation and distant metastasis. Conclusion S100A7 is overexpressesd in ICC, which is helpful to evaluate the prognosis of patients with ICC.
LU Xiaoliang
,
WU Bin
,
CHEN Keji
,
LI Aijun
,
FAN Fei
. Expression of S100A7 in intrahepatic cholangiocarcinoma and its clinical significance[J]. Surgical Research and New Technique, 2021
, 10(1)
: 4
-8
.
DOI: 10.3969/j.issn.2095-378X.2021.01.002
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