Objective To observe the effect of implantation of implantable collamer lens with a central hole （ICL V4C） on intraocular pressure in patients with myopia. Methods Clinical data of 24 cases （48 eyes） from January 2016 to January 2017 were retrieved. All patients received ICL V4C implantation by the same operator. The patients were aged 21 to 45 years, average （32.8±6.5） years. The equivalent ball mirror was -4D~-18D, average （8.25±4.5） D. The astigmatism was between -0.5 D and -4 D, average （1.25±0.75） D. The intraocular pressure ranged between 10-21 mmHg with an average of （15.9±2.82） mmHg. The postoperative arch height was 150-750 μm. The patients were followed up for three years to observe the effect of ICL V4C implantation on intraocular pressure. Results The intraocular pressure values of patients at 1 week, 1 month, 3 months, 6 months, 1 year, 2 years, and 3 years after the operation were all within the range of 10-21 mmHg, which did not exceed threshold. The difference between the two eyes were all less than 5 mmHg and significantly lower than that of the control group （P<0.05）. Conclusion The intraocular pressures of myopic patients are all within a normal and safe range after ICL V4C implementation, and are not obviously changed three years after the surgery compared with before.