Objective To analyze the effects of different anesthesia methods on postoperative outcome of patients with laparoscopic radical resection of colorectal cancer. Methods A retrospective analysis was performed on 90 patients undergoing laparoscopic radical resection of colorectal cancer admitted from January 2019 to June 2020. Among them, 30 patients admitted from January 2019 to June 2019 were selected as intravenous analgesia group and given general anesthesia combined with intravenous analgesia; 30 patients admitted from July 2019 to December 2019 as epidural analgesia group and given general anesthesia combined with epidural analgesia; and 30 patients admitted from January 2020 to June 2020 as transversus abdominis plane block group and given general anesthesia combined with transversus abdominis plane block. The time of spontaneous breathing recovery, eye opening, tracheal removal, and gastrointestinal tract recovery, and the pain degree of the three groups were compared. Results After the operation, the spontaneous breathing recovery time, eye opening time, tracheal removal time, and gastrointestinal recovery time of the epidural analgesia group and the transversus abdominis plane block group were shorter than those of the intravenous analgesia group （P<0.05）. At postoperative 4 h, 6 h, and 12 h, the VAS scores of the epidural analgesia group and the transversus abdominis plane block group were lower than those of the intravenous analgesia group （P<0.05）. Conclusion General anesthesia combined with epidural analgesia or transversus abdominis plane block is beneficial to the postoperative outcome of patients undergoing laparoscopic radical resection of colorectal cancer, and reduce pain as well.