Objective To explore the relationship of clinical significance and prognosis between patients with mild traumatic brain injury (mTBI) and glial fibrillary acidic protein breakdown products(GFAP-BDPs) change.Methods Detected by ELISA in 47 cases of mild head injury patients and 20 healthy subjects serum GFAP-BDPs content,and the Results were compared.Comparison the serum concentrations of GFAP-BDPs between the 27 cases of head CT negative mTBI patients and the 20 cases of head CT positive mTBI patients.The relationship was assessed between the GOS-E score of mTBI patient after 6 months and the concentrations of GFAP-BDPs in the serum of patients.Results Serum of patients with mild head injury GFAP-BDPs were significantly higher than that of the control group (P<0.05).Conclusion GFAP-BDPs serum can be used as diagnostic biomarkers of mTBI,It has a certain accuracy that serum GFAP-BDPs levels can identify patients with positive and negative head CT; The higher levels of serum GFAP-BDPs worse prognosis.
XUE Long
,
YAO Rong-feng
,
GE Ling
,
HUANG Xiao-wei
,
CHEN Jie-bo
. The relationship between mild traumatic brain injury (mTBI) and serum glial fibrillary acidic protein breakdown products (GFAP-BDPs ) change[J]. Surgical Research and New Technique, 2014
, 3(1)
: 24
-27
.
DOI: 10.3969/j.issn.2095-378X.2014.01.005
[1] Zasler N D,Katez D I,Zafonte R D.Brain injury medicine:Principles and practice [M].Now York:Demos Medical Publishing,LLC,2007:45-56.
[2] Narayan RK,Michel ME,Ansell B,et al.Clinical trials in head injury[J].J Neurotrauma,2002,19(5):503-557.
[3] 胡锦,姚海军,刘永,等.华东地区颅脑创伤流行病学调查[J].中华神经外科杂志,2008,24(2):88-91.
[4] 袁强,刘华,姚海军,等.华东地区颅脑交通伤临床及流行病学特点[J].中华神经外科疾病研究杂志,2011,10(3):208-213.
[5] Langlois JA,Rutland-Brown W,Wald MM.The epidemiology and impact of traumatic brain injury:a brief overview[J].J Head Trauma Rehabil,2006,21(5):375-378.
[6] Wade SL,Taylor HG,Drotar D,et a1.A prospective study of long-term caregiver and family adaptation following brain injury in children[J].J Head Trauma Rehabil,2002,17(2):96-111.
[7] Eng LF,Vanderhaeghen JJ,Bignami A,et al.An acidic protein isolated from fibrous astrocytes[J].Brain Res,1971,28(2):351-354.
[8] Dvorak F,Haberer I,Sitzer M,et al.Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke[J].Cerebrovasc Dis,2009,27(1):37-41.
[9] Papa L,Lewis LM,Falk JL,et al.Elevated levelsof serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracraniallesions and neurosurgical intervention[J].Ann Emerg Med,2012,59(6):471-483.
[10] Metting Z,Wilczak N,Rodige LA,et al.GFAP and S100B in the acute phase of mild traumatic brain injury[J].Neurology,2012,78(18):1428-1433.
[11] 陈洁波,薛龙,葛岭,等.颅脑外伤患者血清S100B蛋白含量变化与预后关系研究[J].中华临床医护月刊,2013,11(7):30-31.
[12] 薛龙,尧荣凤,陈洁波,等.颅脑损伤患者血清心脏型脂肪酸结合蛋白含量变化与预后关系研究[J].中华脑科疾病与康复杂志,2013,3(6):419-421.
