Objective To observe the clinical effect of laparoscopic cholecystectomy in combination with common bile duct exploration and lithotripsy on cholecystolithiasis combined with choledocholithiasis. Methods Eighty patients with cholecystolithiasis complicated with choledocholithiasis in our hospital were divided into a control group （n=40）, who underwent routine laparotomy, and an observation group （n=40）, who underwent laparoscopic common bile duct exploration and lithotripsy. The results of surgical treatment, quality of life scores, and VAS pain scores before and after operation were compared between the groups. Results The abdominal drainage time and hospitalization time in the observation group were shorter than those in the control group （P<0.05）. No differences were found in the quality of life scores and VAS pain scores before treatment between the two groups; but after treatment, the quality of life scores and VAS pain scores in the observation group were also shorter than those in the control group （P<0.05）. Conclusion Cholecystectomy in combination with laparoscopic common bile duct exploration and lithotripsy for cholecystolithotomy combined with choledocholithiasis can effectively improve the curative effect and promote the recovery of patients, which is worth promoting.