Objective To investigate the effect of timing and mode of labor analgesia during labor induction with oxytocin on pregnancy outcome. Methods A total of 260 parturients requiring labor analgesia induced by oxytocin in Shanghai Putuo District Maternal and Child Health Hospital from January to July 2020 were randomly divided into an early catheterization analgesia group （n=130） and a routine analgesia group （n=130） according to labor analgesia program. The delivery outcome, duration of labor, lateral incision rate, amount of postpartum hemorrhage, and Visual Analogue Scale （VAS） score were compared between the two groups. Results The VAS score before analgesia in the early catheterization analgesia group was significantly lower than that in the routine analgesia group （7.82±0.92 vs. 8.34±0.83, P<0.05）. Although the VAS score after catheterization in the early catheterization analgesia group was slightly higher than that in the routine analgesia group （4.60±0.75 vs. 4.19±0.85, P<0.05）, there was no significant difference in the score after analgesia between the two groups （3.91±0.71 vs. 3.88±0.69, P>0.05）. There were no significant differences in the time of labor, the rate of lateral incision,the amount of postpartum hemorrhage, the rate of forceps delivery, and the rate of cesarean section between the two groups. Conclusion Early catheterization analgesia can relieve uterine contraction pain in the early stage of labor when the VAS score is low, while not affecting labor, not increasing the bleeding rate, lateral incision rate, vaginal delivery rate, and cesarean section rate, and not reducing the neonatal score. It helps relieve the negative mood of pregnant women, and improve the outcome of vaginal delivery,thus is worth popularizing.