Objective To build a smart hospital in response to and in accordance with the State Food and Drug Administration’s regulations on UDI management of medical devices （YY/T 1630-2018）, to strengthen the construction of smart hospital and the medical management by information technology means in line with the Opinions of the General Office of the State Council on Promoting the Development of “Internet + Medical Health”, and to be prepared for upcoming smart service grading review of tertiary hospitals in 2019. Methods The Equipment Department and Surgical Department of Huashan Hospital applied UDI-based Internet of Things technology in the original information management platform. Results An RFID-based intelligent warehouse management system was established to manage high-value consumables and surgical instruments. Conclusion The established system solved a series of management difficulties, such as UDI assignment of high-value consumables, automatic inventory and input of high-value consumables, traceability of consumables, management of expiry date, management of inventory, and management of medical adverse reactions.