Objective To study the effect of laparoscopic inguinal hernia repair with ultrasound-guided transversus abdominis plane （TAP） combined with iliohypogastric nerve block and to analyze the complications. Methods From August 2019 to July 2021, a total of 80 patients who planned to undergo laparoscopic inguinal hernia repair were included in this study. The patients were divided into a combined treatment group and a control group, with 40 cases in each group. The control group received ultrasound-guided TAP block, while the combined group received ultrasound-guided TAP combined with iliohypogastric nerve block. The mean arterial pressure （MAP）, heart rate （HR）, and blood oxygen saturation （SpO₂） levels at different time points during perioperative period were compared between the two groups, as well as the pain and complications at different time points after block. Results The MAP levels of the combined treatment group at 10 min after anesthesia and at pulling the hernia were higher than the levels of the control group （P<0.05）, and there were no significant differences in HR and SpO₂ levels between the two groups at different time periods （P>0.05）. The VAS scores of the combined treatment group at 2 h, 6 h, 12 h, 24 h, and 48 h after block were lower than the scores of the control group （P<0.05）. The incidence rates of nausea and vomiting, heart rate increase, and blood pressure increase in the combined treatment group were 2.50%, 0.00%, and 0.00%, respectively, which were all lower than those of the individual treatment group （17.50%, 10.00%, and 10.00%; P<0.05）. Conclusion Laparoscopic inguinal hernia repair with ultrasonic-guided TAP combined with iliohypogastric nerve block is beneficial to maintain hemodynamic stability, has significant analgesic effects, and can effectively reduce the incidence of complications.