Objective To discuss the effect of surgical treatment on obstructive sleep apnea syndrome （OSAS） patients with laryngopharyngeal reflux （LPR）. Methods A total of 56 OSAS patients with LPR were selected from June 2017 to December 2019. Surgical effects were reported. Results Among the 56 patients, the incidence rates of preoperative clinical symptoms such as hoarseness, hawking, excessive phlegm or running nose, dysphagia, cough upon lying down, breathing difficulty or asphyxia, chronic cough, foreign body sensation in throat, and sour regurgitation or heartburning were 8.93%, 10.71%, 14.29%, 7.14%, 12.5%, 8.93%, 17.86%, 12.5%, and 7.14%, respectively; the incidence rates of clinical signs like sulcus vocalis, disappeared ventriculus larynges, laryngeal edema, erythema or congestion, granuloma, posterior commissure proliferation, and vocal edema were 16.07%, 16.07%, 21.43%, 17.86%, 8.93%, 10.71%, and 8.93%, respectively. The apnea hypopnea index （AHI） after surgery was lower than before; the oxygen saturation （SaO₂） level was higher than before; the total effective rate was 92.86%. The reflux symptom index （RSI） item scores after surgery were lower than before （P<0.05）. The reflux finding score （RFS） results showed that except the granuloma and posterior commissure proliferation scores （P>0.05）, the remaining RFS item scores before and after surgery were significantly different （P<0.05）. Conclusion The surgical treatment for OSAS patients with LRP can efficiently relieve airway stenosis and choking, and improve reflux signs, showing a significant clinical effect.