Objective To analyze the effect of carboprost tromethamine plus balloon compression on pernicious placenta previa. Methods A total of 66 patients with pernicious placenta previa treated from January 2017 to January 2020 were selected as study subjects. According to random number table, the patients were divided into a routine group （33 cases） and a test group （33 cases）. The routine group took gauze packing and carboprost tromethamine; the test group took balloon compression and carboprost tromethamine. The bleeding volumes during surgery and after 2 h and 24 h of surgery, total effective rate, hemostasis time, and hospital stays were compared between the two groups. Results During surgery and after 2 h and 24 h of surgery, the bleeding volumes in the test group were significantly less than the volumes in the routine group （P<0.05）. The total effective rates in the test group and the routine group were 93.94% and 75.76% respectively, showing a significant difference （P<0.05）. The hemostasis time and hospital stays in the test group were shorter than those of the routine group （P<0.05）. Conclusion Balloon compression combined with carboprost tromethamine is effective in the treatment of pernicious placenta previa, as it can reduce bleeding volume, increase treatment effects, and shorten hemostasis time and hospital stays.