Objective To explore the effect of comprehensive prenatal care on the outcome of childbirth in pregnant women with scar uterus. Methods A total of 120 pregnant women with scar uterus admitted from October 2019 to April 2020 were selected as study subjects, and were divided into a control group （60 cases with odd number） and an observation group （60 cases with even number） accorded to the number of ward bed. The control group ordered routine prenatal examination, prenatal care, and delivery evaluation, while the observation group received comprehensive prenatal care. The time of the first, second, and third stages of labor were recorded, and the outcomes of delivery （number of successful vaginal delivery, number of caesarean section delivery, fetal distress, neonatal asphyxia, neonatal Apgar score, birth weight, and postpartum hemorrhage） were compared between the two groups, and the satisfaction between the two groups of maternal care services was compared. Results The first, second, and third stages of labor were shorter in the observation group than those in the control group （P<0.05）. The rate of vaginal delivery and Apgar score of newborns in the observation group were all higher than those in the control group, and the rate of cesarean section, fetal distress, neonatal asphyxia, birth weight, and postpartum hemorrhage in the observation group were all lower than those in the control group （P<0.05）. The satisfaction rate of the observation group was higher than that of the control group （P<0.05）. Conclusion Comprehensive prenatal care for pregnant women with scar uterus can reduce labor time, fetal distress, neonatal asphyxia, neonatal weight, and postpartum hemorrhage, as well as increase the success rate of vaginal delivery, the Apgar score of newborn, and mothers’ satisfaction with nursing services.