Objective To prepare oxidized regenerated cellulose/chitosan （ORC-CTS） hemostatic sponges, and study its properties. Methods ORC-CTS hemostatic sponges were prepared and characterized. The hemostatic properties and prognostic effects of ORC-CTS, chitosan, and surgicel were compared by hemostasis test, inflammation test, and toxicity test in vivo. Results The blood loss in the ORC-CTS group was less than that in the control group, the chitosan group, and the surgicel group （all P<0.05）; the hemostasis time in the ORC-CTS group was shorter than that in the control group, the chitosan group, and the surgicel group （all P<0.05）. The degree of inflammation ranked as control group<ORC-CTS group<chitosan group<surgicel group. No significant differences in serum tumor necrosis factor （TNF-α）, isoprostanes, and von Willebrand Factor （vWF） were found between the ORC-CTS group and the control group. Conclusion ORC-CTS hemostatic sponges can reduce blood loss, shorten bleeding time, stimulate mild inflammatory reaction, show good biocompatibility and little toxicity, thus may be an ideal new hemostatic material.
HUANG Zhishu
,
ZHOU Lixin
,
SU Jiqin
,
YAN Huidi
,
LIN Yanli
. Preparation and properties of oxidized regenerated cellulose/chitosan （ORC-CTS） hemostatic sponges[J]. Surgical Research and New Technique, 2021
, 10(3)
: 167
-171
.
DOI: 10.3969/j.issn.2095-378X.2021.03.003
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