Objective To investigate the relationships of peritumor retraction clefting with vascular invasion, nerve involvement, and lymph node metastasis in common colorectal adenocarcinoma. Methods The clinicopathological data of 196 patients with common colorectal adenocarcinoma who were pathologically diagnosed from April 2016 to December 2019 were retrieved, and their clinicopathological features such as peritumor retraction clefting, vascular invasion, nerve involvement, and lymph node metastasis were retrospectively analyzed. The diagnosis was reviewed according to the fourth edition of WHO classification of gastrointestinal tumors, and the patients were divided into two groups： 66 cases of non-peritumor retraction clefting and 130 cases of peritumor retraction clefting. The peritumor retraction clefting group was further divided into two subgroups according to extent of retraction clefts： ≥20% retraction clefts, 42 cases;<20% retraction clefts, 88 cases. SPSS 19.0 statistical software was used to analyze the relationships with vascular invasion, nerve involvement, and lymph node metastasis in each group. Results The peritumor retraction clefting group had significantly higher incidence rates of vascular invasion, nerve involvement, and lymph node metastasis than the non-peritumor retraction clefting group （P<0.05）. The peritumor retraction clefting group without vascular invasion had a higher incidence of lymph node metastasis than the non-peritumor retraction clefting group without vascular invasion （P<0.05）, but lower than the peritumor retraction clefting group with vascular invasion （P<0.05）, and had no relationship with the extent of peritumor retraction clefts （P>0.05）. Conclusion The appearance of peritumor retraction clefting in colorectal adenocarcinoma is positively correlated with vascular invasion, nerve involvement, and lymph node metastasis, indicating a poor prognosis.
LIU Liwei
,
YI Xianghua
,
ZHANG Tingting
,
WU Yunjin
,
FAN Desheng
. Relationship between peritumor retraction clefting and prognosis： A retrospective analysis of 130 cases of colorectal carcinoma[J]. Surgical Research and New Technique, 2021
, 10(3)
: 172
-175
.
DOI: 10.3969/j.issn.2095-378X.2021.03.004
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