Objective To evaluate the clinical effect of minimally invasive rotary surgery on benign breast lesions. Methods The clinical data of 127 patients with benign breast lesions treated from June 2019 to December 2020 were retrospectively analyzed. According to treatment methods, they were divided into a control group （60 cases treated with conventional breast mass resection） and a study group （67 cases treated with minimally invasive rotary surgery）. The epinephrine （E） level, norepinephrine （NE） level, operation time, scar length, wound healing time, tumor residual rate, and complication rate were compared between the two groups. Results After treatment, the levels of E and NE in the study group were lower than those in the control group （P<0.05）; the operation time, scar length, and wound healing time in the study group were shorter than those in the control group （P<0.05）; the residual rate of mass in the study group was 1.49%, lower than 10.00% in the control group （P<0.05）; the incidence rate of complications in the study group was 2.99%, lower than 16.67% in the control group （P<0.05）. Conclusion The treatment of benign breast lesions with minimally invasive rotary surgery can shorten operation time and wound healing time, reduce scar hyperplasia and surgical stress response, increase mass clearance rate, with less complications and good safety.