[1] 陈万青,张思维,郑荣寿,等.中国2009年恶性肿瘤发病和死亡分析[J].中国肿瘤,2013,22(1):2.
[2] Folkman J.Role of angiogenesis in tumor growth and metastasis[J].Semin Oncol,2002,29(6):15-18.
[3] Al-Rawi MAA,Jiang WG.Lymphangiogenesis and cancer metastasis[J].Front Biosci-Landmrk,2011,16(7):723-739.
[4] Mehrazma M,Mahjoob F,Rafsanjani KA,et al.VEGF and p53 Biomarkers in Pediatric Patients With Langerhans Cell Histiocytosis[J].J Pediat Hematol Oncol,2013,35(7):E292-E295.
[5] Zhao SF,Yang XD,Lu MX,et al.Prognostic significance of VEGF immunohistochemical expression in oral cancer:a meta-analysis of the literature[J].Tumor Biol,2013,34(5):3165-3171.
[6] Wu S,Wu XQ,Zhu W,et al.Immunohistochemical study of the growth factors,aFGF,bFGF,PDGF-AB,VEGF-A and its receptor (Flk-1) during arteriogenesis[J].Mol Cell Biochem,2010,343(1-2):223-229.
[7] Rozman A,Silar M,Kosnik M.Angiogenin and vascular endothelial growth factor expression in lungs of lung cancer patients[J].Radiol Oncol,2012,46(4):354-359.
[8] Achen MG,McColl BK,Stacker SA.Focus on lymphangiogenesis in tumor metastasis[J].Cancer Cell,2005,7(2):121-127.
[9] Kyzas PA,Geleff S,Batistatou A,et al.Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma[J].J Pathol,2005,206(2):170-177.
[10] Semenza GL.Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis,lymphangiogenesis,and metastasis[J].Oncogene,2013,32(35):4057-4063.
[11] Pasquali S,van der Ploeg APT,Mocellin S,et al.Lymphatic biomarkers in primary melanomas as predictors of regional lymph node metastasis and patient outcomes[J].Pigm Cell Melanoma R,2013,26(3):326-337.
[12] Karpanen T,Heckman CA,Keskitalo S,et al.Functional interaction of VEGF-C and VEGF-D with neuropilin receptors[J].Faseb J,2006,20(9):1462-1472.
[13] Salameh A,Galvagni F,Bardelli M,et al.Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation,migration,and survival of endothelial cells through the activation of ERK,AKT,and JNK pathways[J].Blood,2005,106(10):3423-3431.
[14] Cross MJ,Dixelius J,Matsumoto T,et al.VEGF-receptor signal transduction[J].Trends Biochem Sci,2003,28(9):488-494.
[15] Shin JW,Min M,Larrieu-Lahargue F,et al.Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium:A role for FGF signaling in lymphangiogenesis[J].Mol Biol Cell,2006,17(2):576-584.
[16] Wigle JT,Harvey N,Detmar M,et al.An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype[J].Embo J 2002,21(7):1505-1513.
[17] Jianyu H,Yuanfang L.The quantitative expressions of lymphangiogenic factors and metastasis in human colorectal cancers[J].Chinese-German J Clin Oncol,2011,10(3):170-173.
[18] Kubo H,Cao RH,Brakenhielm E,et al.Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea[J].P Natl Acad Sci USA,2002,99(13):8868-8873.
[19] Liu HD,Yang YM,Xiao JB,et al.COX-2 Mediated Regulation of VEGF-C in Association With Lymphangiogenesis and Lymph Node Metastasis in Lung Cancer[J].Cancer Biol,2010,293(11):1838-1846.
[20] Al-Rawi MAA,Watkins G,Mansel RE,et al.The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells[J].Int J Oncol,2005,27(3):721-730.
[21] Zhang SQ,Yu H,Zhang LL.Role of vascular endothelial growth factor receptor-3/Flt-4 in early-stage cervical cancer[J].Oncol Lett,2010,1(3):453-456.
[22] Achen MG,Mann GB,Stacker SA.Targeting lymphangiogenesis to prevent tumour metastasis[J].Brit J Cancer,2006,94(10):1355-1360.
[23] Laakkonen P,Waltari M,Holopainen T,et al.Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth[J].Cancer Res,2007,67(2):593-599.
[24] Braun M,Flucke U,Debald M,et al.Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin):a clinically useful predictor for axillary lymph node metastases[J].Breast Cancer Res Tr,2008,112(3):503-511.
[25] Pula B,Wojnar A,Werynska B,et al.Impact of different tumour stroma assessment methods regarding podoplanin expression on clinical outcome in patients with invasive ductal breast carcinoma[J].Anticancer Res,2013,33(4):1447-1455.
[26] McElroy M,Hayashi K,Garmy-Susini B,et al.Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo[J].J Surg Res,2009,151(1):68-73.
[27] Expression of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) on macrophages in rat subcutaneous connective tissue[J].Faseb J,2008,22.
[28] Carreira CM,Nasser SM,Tomaso ED,et al.LYVE-1 is not restricted to the lymph vessels expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis[J].Cancer Res,2001,22(61):8079-8084.
[29] Rose AE,Christos PJ,Lackaye D,et al.Clinical relevance of detection of lymphovascular invasion in primary melanoma using endothelial markers D2-40 and CD34[J].Am J Surg Pathol,2011,35(10):1441-1449.
[30] 陈文静,张江宇,李文萍.D2-40在肿瘤淋巴管标记及诊断的研究进展[J].中华临床医师,2011,5(4):110-112.
[31] Cai JH,Ikeguchi M,Maeta M.Micrometastasis in lymph nodes and microinvasion of the muscularis propria in primary lesions of submucosal gastric cancer[J].Surgery,2000,127(1):32-39.
[32] Balic M,Williams A,Dandachi N,et al.Micrometastasis:Detection methods and clinical importance[J].Cancer Biomark,2011,9(1-6):397-419.
[33] Krishnamurthy S,Meric-Bernstam F,Lucci A,et al.A prospective study comparing touch imprint cytology,frozen section analysis,and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer[J].Cancer,2009,115(7):1555-1562.
[34] Tamaki Y,Akiyama F,Iwase T,et al.Molecular detection of lymph node metastases in breast cancer patients:Results of a multicenter trial using the one-step nucleic acid amplification assay[J].Clin Cancer Res,2009,15(8):2879-2884.
[35] Denninghoff V,Allende D,Paesani F,et al.Sentinel lymph node molecular pathology in breast carcinoma[J].Diagn Mol Pathol,2008,17(4):214-219.
[36] Celebioglu F,Sylvan M,Perbeck L,et al.Intraoperative sentinel lymph node examination by frozen section,immunohistochemistry and imprint cytology during breast surgery—A prospective study[J].Eur J Cancer,2006,42(5):617-620.
[37] Krishnan J,Kirkin V,Steffen A,et al.Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats[J].Cancer Res,2003,63(3):713-722.
[38] Pytowski B,Goldman J,Persaud K,et al.Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody[J].J Natl Cancer,2005,97(1):14-21.
