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Review

Review on correlation between connexin 32 and liver homeostasis

  • XU Yan ,
  • SHI Baomin
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  • Department of General Surgery, Tongji Hospital Affiliated to Tongji University, Shanghai 200065, China

Received date: 2021-02-23

  Online published: 2022-08-22

Abstract

The roles of intercellular communication in maintaining homeostasis in tissues, organs, and even individuals are of the utmost importance. Gap junction (GJ) acts as a vital medium. As a popular organ of interest, the liver is the first organ to be studied in the field of GJ. Cx32, a liver-specific connexin (Cx) constituting more than 90% of liver GJ, plays an important role in cell proliferation and differentiation, tissue functioning and homeostasis, pathophysiological changes, toxicological injury, and cell carcinogenesis. Hence, understanding the diverse changes in the expression, localization, and function of Cx32, and carrying out research on associated mechanism of action may help explore new methods for the treatment of liver diseases in the future. This paper reviewed the correlation between Cx32 and liver homeostasis.

Cite this article

XU Yan , SHI Baomin . Review on correlation between connexin 32 and liver homeostasis[J]. Surgical Research and New Technique, 2021 , 10(4) : 295 -299 . DOI: 10.3969/j.issn.2095-378X.2021.04.014

References

[1] Loewenstein WR, Kanno Y.Intercellular communication and tissue growth I cancerous growth[J]. J Cell Biol, 1967, 33(2):225-234.
[2] Aasen T, Mesnil M, Naus CC, et al.Gap junctions and cancer: communicating for 50 years[J]. Nat Rev Cancer, 2016,16(12): 775-788.
[3] Revel JP, Karnovsky MJ.Hexagonal array of subunits in intercellular junctions of the mouse heart and liver[J]. J Cell Biol, 1967, 33(3): C7-C12.
[4] Graham SV, Jiang JX, Mesnil M.Connexins and pannexins: important players in tumorigenesis, metastasis and potential therapeutics[J]. Int J Mol Sci, 2018, 19(6):1645.
[5] Söhl G,Willecke K.An update on connexin genes and their nomenclature in mouse and man[J]. Cell Commun Adhes, 2003,10(4):173-180.
[6] Beyer EC, Berthoud VM.Gap junction gene and protein families: connexins, innexins, and pannexins[J]. Biochim. Biophys. Acta, 2018,1860(1): 58.
[7] Bai D.Structural analysis of key gap junction domains-Lessons from genome data and disease-linked mutants[J]. Semin Cell Dev Biol, 2016, 50(11):74-82.
[8] Goodenough DA, Paul DL.Gap junctions[J]. Cold Spring Harbor Perspect Biol, 2009, 1(1): 002576.
[9] Oyamada M, Oyamada Y, Takamatsu T.Regulation of connexin expression[J].Biochim Biophys Acta, 2006, 1719(1-2): 6-23.
[10] Aasen T, Johnstone S, Vidal-Brime L, et al.Connexins: synthesis, post-translational modifications, and trafficking in health and disease[J]. Int J Mol Sci, 2018,19(5):1296-1332.
[11] Howard W, Evans. Cell communication across gap junctions: a historical perspective and current developments[J]. Biochem Soc Trans, 2015, 43(3):450-459.
[12] Oyamada M, Takebe K, Oyamada Y.Regulation of connexin expression by transcription factors and epigenetic mechanisms[J]. Biochimica Et Biophysica Acta, 2013, 1828(1): 118-133.
[13] Mulkearns-Hubert EE, Reizes O, Lathia JD.Connexins in cancer: Jekyll or Hyde?[J]. Biomolecules, 2020, 10(12):1654.
[14] Zhou JZ, Jiang JX.Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update[J]. FEBS Letters, 2014,588(8):1186-1192.
[15] Vinken M, Papeleu P, Snykers S, et al.Involvement of cell junctions in hepatocyte culture functionality[J]. Crit Rev Toxicol, 2006, 36(4):299-318.
[16] Paul DL.Molecular cloning of cDNA for rat liver gap junction protein[J]. J Cell Biol 1986;103(1):123-134.
[17] Kumar NM, Gilula NB.Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein[J]. J Cell Biol 1986;10(3):767-776.
[18] Meyer DJ.Intercellular communication in normal and regenerating rat liver: a quantitative analysis[J]. J Cell Biol , 1981, 91(2 Pt 1): 505-523.
[19] Temme A, Ott T, Dombrowski F, et al.The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions-ScienceDirect[J]. J Hepatol, 2000,32(4):627-635.
[20] Kojima T, Yamamoto T, Murata M, et al.Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver[J]. Cell Commun Adhes, 2003, 10(4-6): 437.
[21] Masahito O, Kumiko T, Aya E, et al.Connexin expression and gap-junctional intercellular communication in ES cells and iPS cells[J]. Front Pharmacol, 2013, 4(1):85.
[22] Vinken M, Kock JD, André G, et al.Modifications in connexin expression in liver development and cancer[J]. Cell Commun Adhes, 2012,19(3-4): 55-62.
[23] Baxter M, Withey S, Harrison S, et al.Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes[J]. J Hepatol, 2015, 62(3):581-589.
[24] Qin J, Chang M, Wang S, et al.Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells[J]. Sci Rep, 2016, 6(1):373-388.
[25] Pei H, Zhai C, Li H, et al.Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes[J]. Stem Cell Res Ther, 2017, 8(1):252.
[26] Wilson MR, Close TW, Trosko JE.Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis[J]. Exp Cell Res, 2000, 254(2): 257-268.
[27] Albright CD, Kuo J, Jeong S. cAMP enhances Cx43 gap junction formation and function and reverses choline defificiency apoptosis[J]. Exp Mol Pathol, 2001,71(1):34-39.
[28] Vinken M, Henkens T, Rop ED, et al.Biology and pathobiology of gap junctional channels in hepatocytes[J]. Hepatology, 2010, 47(3):1077-1088.
[29] Vinken M, Decrock E, Vuyst ED, et al.Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death[J]. Cell Mol Life Sci, 2010, 67(6):907-918.
[30] Vinken M.Gap junctions and non-neoplastic liver disease[J]. J Hepatol, 2012, 57(3): 655-662.
[31] Tiburcio TC,Willebrords J, Da Silva TC, et al.Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non‐alcoholic steatohepatitis[J]. Clin Exp Pharmacol Physiol, 2017, 44(2): 197-206.
[32] Sagawa H, Naiki-Ito A, Kato H, et al.Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats[J]. Carcinogenesis, 2015,36(12):1539-1549.
[33] Igarashi I, Maejima T, Kai K, et al.Role of connexin 32 in acetaminophen toxicity in a knockout mice model[J]. Exp Toxicol Pathol, 2014, 66(2-3):103-110.
[34] Cogliati B, Crespo Yanguas S, Da Silva TC, et al.Connexin32 deficiency exacerbates carbon tetrachloride-induced hepatocellular injury and liver fibrosis in mice[J]. Toxicol Mech Methods, 2016, 26(5):362-370.
[35] Patel SJ, Milwid JM, King KR,et al.Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure[J]. Nat Biotechnol, 2012, 30(2):179-183.
[36] Asamoto M, Hokaiwado N, Murasaki T, et al.Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals[J]. Hepatology, 2010,40(1):205-210.
[37] Naiki-Ito A, Asamoto M, Naiki T, et al.Gap junction dysfunction reduces acetaminophen hepatotoxicity with impact on apoptotic signaling and connexin 43 protein induction in rat[J]. Toxicol Pathol, 2010, 38(2):280-286.
[38] Maes M, Mcgill MR, Da Silva T C, et al. Connexin32: a mediator of acetaminophen-induced liver injury?[J]. Toxicol Mech Methods, 2016,26(2): 88-96.
[39] Maes M, Crespo Yanguas S, et al.Connexin and pannexin signaling in gastrointestinal and liver disease[J].Transl Res, 2015; 166(4): 332-343.
[40] Evert M, Ott T, Temme A, et al.Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice[J]. Carcinogenesis, 2002, 23(5):697-703.
[41] Schwarz M, Wanke I, Wulbrand U, et al.Role of connexin32 and beta-catenin in tumor promotion in mouse liver[J]. Toxicol Pathol, 2003, 31(1):99-102.
[42] Sinyuk M, Mulkearns-Hubert EE, Reizes O, et al.Cancer Connectors: connexins, gap junctions, and communication[J]. Front Oncol, 2018, 8(8):646-654.
[43] Igarashi I, Makino T, Suzuki Y, et al.Background lesions during a 24-month observation period in connexin 32-deficient mice[J]. J Vet Med Sci, 2013,75(2):207-210.
[44] Evert M, Ott T, Temme A, et al.Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32deficient mice[J]. Carcinogenesis, 2002, 23(2):697-703.
[45] Yang Y, Yao JH, Du QY, et al.Connexin 32 downregulation is critical for chemoresistance in oxaliplatin-resistant HCC cells associated with EMT[J]. Cancer Manag Res, 2019, 11(1), 5133-5146.
[46] Naus CC, Laird DW.Implications and challenges of connexin connections to cancer[J]. Nat Rev Cancer, 2010,10(6):435-441.
[47] Li Q,Omori Y,Nishikawa Y,et al.Cytoplasmic accumulation of connexin32 protein enhances motility and metastatic ability of human hepatoma cells in vitro and in vivo[J]. Int J Cancer, 2007,121(3):536-546.
[48] Xiang Y, Wang Q, Guo Y, et al.Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma[J]. J Exp Clin Cancer Res, 2019, 38(1): 145.
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