Objective To compare the clinical effects of small splint fixation versus plaster fixation on distal radius fractures. Methods From January 2019 to December 2021, a total of 64 patients with distal radius fractures were enrolled into this study. In terms of treatment options, 32 patients received small splint fixation, while the remaining 32 patients had plaster fixation. After 3 months of follow-up, the excellent and good rate of postoperative Gartland-Werley score and the wrist joint function recovery assessed by Wrist Function Cooney scoring system were compared between the two groups. Results The excellent and good rate of the group treated with small splint fixation was 89.7%, while the rate of the group treated with plaster fixation was 82.2%. At last follow-up, the Cooney score of the small splint fixation group was higher than that of the plaster fixation group （P<0.05）. Conclusion Small splint fixation in the treatment of distal radius fractures can improve wrist joint function, reduce pain, promote fracture healing, and reduce complications, which is worthy of clinical application and promotion.