The disposal of medical supplies plays a very important role in public health emergency logistic support. As one of the important parts in epidemic prevention and control, the disposal of medical materials after the closure of large shelter hospitals is crucial for the full utilization of medical equipment and medical consumables, the proper placement of state-owned assets, and the conservation of medical resources. This paper summarized the practical experience in the disposal and management of medical materials after the closure of the Fangcang Shelter Hospital of the National Convention and Exhibition Center （Shanghai）, focused on the principle of "overall allocation, full utilization, step-by-step implementation, and combination of use and storage", and formed a material disposal management system through the establishment of material disposal organization structure, division of responsibilities, and operation mechanism, in order to provide reference for further improving the management system of medical material disposal in public health events.