Objective To analyze the clinical effects of hybrid surgery, laparoscopic surgery, and open surgery on abdominal incisional hernia. Methods The clinical data of 90 patients with abdominal incisional hernia admitted from January 2018 to December 2021 were retrospectively analyzed. According to the operation method, they were divided into hybrid group, laparoscopic group, and open group, with 30 cases in each group. Operation time, intraoperative blood loss, hospital stay, and postoperative complications were compared among the three groups. Results There were significant differences in operation time, intraoperative blood loss, and hospital stay among the three groups (P<0.05). Pairwise comparison results showed that the operation time of the hybrid group was significantly longer than those of the laparoscopic group and the open group (P<0.05), but there was no significant difference between the laparoscopic group and the open group (P>0.05). The amount of intraoperative blood loss in the hybrid group was significantly less than that in the open group (P<0.05). There was no significant difference in the amount of intraoperative blood loss between the hybrid group and the laparoscopic group, and between the laparoscopic group and the open group (P>0.05). There was no significant difference in the length of hospital stay between the hybrid group and the laparoscopic group (P>0.05), but both were shorter than that of the open group (P<0.05). There were significant differences in postoperative complications among the three groups (P<0.05). Conclusion The three surgical methods have their own advantages and disadvantages in the treatment of abdominal incisional hernia. Operators should understand the indications of various surgical methods and choose the appropriate surgical method according to the actual situation of the patient, so as to achieve the optimal treatment approach and the best therapeutic effects.