Objective To investigate the clinical outcomes of simultaneous transurethral intracavitary and minimally invasive surgery for benign prostatic hyperplasia (BPH) with bladder stones. Methods A total of 130 patients with BPH and bladder stones admitted to Funing People's Hospital from January 2016 to July 2021 were selected and randomly divided into an observation group and a control group, with 65 cases in each group. In the observation group, transurethral barometric trajectory lithotomy (TUBTL) or transurethral holmium laser lithotripsy (TUHLL) was performed, and transurethral plasmakinetic resection of prostate (PKRP) was performed at the same time. In the control group, only TUBTL or TUHLL was performed. The patients in the two groups were compared in surgery-related indicators and the improvement of symptoms before and after surgery. Results All operations were successful. The lithotomy time was 8-35 min, (17±5.6) min in average. Specifically, the time was 8-20 (14±3.2) min for TUHLL and 10-35 (18±6.2) min for TUBTL. The postoperative hospital stay was 5-8 (6.9±0.6) d. In the observation group, the operation time for PKRP was 26-125 (65±28.2) min, and the blood loss amount was 60-350 (110±54.5) mL. Preoperaitve IPSS, Q_max, and RU were not significantly different between the two groups (P>0.05). The postoperative IPSS, Q_max, and RU in the observation group were significantly better than the preoperative indicators in the same group and the postoperative indicators in the control group (P<0.05). In the observation group, no recurrence of stones was seen on postoperative kidney/ureter/bladder (KUB) radiographs, and there were no complications such as urinary incontinence and haematuria. Conclusion The use of TUBTL/TUHLL and PKRP at the same time is safe and efficient in the treatment of BPH and bladder stones, with few complications, and significantly improves patients' symptoms, deserving wide application.