Objective To investigate the effects of Mammotome breast minimally invasive rotary resection on breast benign tumor and aesthetic appearence. Methods A total of 110 female patients with benign breast tumors admitted from August 2019 to January 2022 were selected as study subjects, and the patients were divided into the Mammotome group and the control group （55 cases each） according to the random number table method. The control group was given traditional breast tumor surgical treatment, and the Mammotome group was given Mammotome breast minimally invasive rotational treatment to observe the treatment effect and aesthetic changes. Results All patients completed the operation, and no serious complications occurred. The postoperative hospital stay and intraoperative blood loss in the Mammotome group were significantly reduced compared with the control group, and the difference in surgical time was not statistically significant （P>0.05）. The complication rates of incisional hematoma, incisional infection, and venous thrombosis at 1 month after surgery in the Mammotome group was lower than those in the control group （P<0.05）. The aesthetic effect scores such as breast shape, nipple sensation, and pigmentation at 1 month after surgery were higher in the Mammotome group than in the control group （P<0.05）. Conclusion Mammotome minimally invasive rotary resection can reduce the intraoperative bleeding and postoperative hospital stay, improve the beauty effects, reduce the occurrence of complications of patients with breast benign tumor, the rate of axillary lymph node metastasis and distant metastasis were decreased.