Objective To explore the effects of laparoscopic radical gastrectomy with different approaches on gastrointestinal function and serum inflammatory factor levels in patients with gastric cancer. Methods A total of 120 gastric cancer patients diagnosed and treated from July 2019 to July 2022 were selected and divided into a control group and an observation group according to random number table method, with 60 cases in each group. Both groups underwent laparoscopic radical gastrectomy, in which the control group underwent a left posterior approach and the observation group underwent a right anterior approach. Gastrointestinal function scores and serum inflammatory factor [interleukin-6 （IL-6）, hypersensitive C-reactive protein （hs-CRP）] levels were compared between the two groups before and after surgery. Results Postoperative gastrointestinal function scores of the observation group were lower than preoperative scores and those of the control group （P<0.05）. The levels of IL-6 and hs-CRP in the observation group were lower than those in the control group （P<0.05）. Conclusion Laparoscopic radical gastrectomy with right anterior approach can reduce inflammatory reaction and promote gastrointestinal function recovery in patients with gastric cancer.