Objective To investigate the effects of diversified nursing on functional rehabilitation and quality of life in patients with hand-foot trauma who underwent vacuum sealing drainage （VSD）. Methods A total of 112 patients with hand and foot trauma treated with VSD in our hospital from June 2022 to April 2023 were selected and divided into an observation group （56 cases） and a control group （56 cases） by random number table method. Patients in the control group received routine nursing intervention, while patients in the observation group received diversified nursing intervention. The functional recovery, quality of life scores （emotion index, life satisfaction index, and health index）, and complications （such as infection, joint stiffness, and folliculitis） were compared between the two groups. Results After intervention, 31 patients in the observation group had excellent functional recovery, 23 cases were good, and 2 cases were poor. The excellent and good rate was 96.4% in the observation group, which was higher than 78.6% in the control group （P<0.05）. There was no difference in the health index, emotion index, and life satisfaction index between the two groups of patients before intervention （P>0.05）, but after intervention, the scores of all indicators in the observation group were higher than those in the control group （P<0.05）. In terms of complications, only 1 case of infection and 1 case of joint stiffness occurred in the observation group, with a complication rate of 3.6%, which was significantly lower than that of 30.4% in the control group （P<0.05）. Conclusion The use of diversified nursing for the intervention of patients with hand and foot trauma after VSD is helpful to promote the functional rehabilitation, reduce the occurrence of complications, and improve the quality of life.