Objective To evaluate the value of different mesh fixation methods in laparoscopic totally extraperitoneal （TEP） herniorrhaphy for inguinal hernia. Methods A total of 100 patients with inguinal hernia treated in Beijing Pinggu District Hospital of Traditional Chinese Medicine from March 2020 to March 2023 were selected and divided into two groups according to different treatment methods： non-fixation group （67 cases, laparoscopic TEP herniorrhaphy with self-fixation mesh） and medical adhesive group （33 cases, laparoscopic TEP herniorrhaphy with traditional mesh）. The clinical data of the two groups were compared and analyzed. Results There was no significant difference between the two groups in operative time and amount of bleeding （P>0.05）. The time of first anal exsufflation, eating after operation, free movement and hospitalization in the non-fixed group were significantly shorter than those in the medical adhesive group （P<0.05）. After treatment, the visual analogue scale （VAS） and short form 36-item health survey （SF-36） scores of both groups were significantly improved （P<0.05）, and the VAS and SF-36 scores at 6 months after operation in the non-fixed group were significantly better than those in the medical adhesive group （P<0.05）. The incidence rate of postoperative complications in the non-fixation group was significantly lower than that in the medical adhesive group （P<0.05）. Conclusion The laparoscopic TEP herniorrhaphy for inguinal hernia with self-fixed mesh can promote the postoperative rehabilitation of patients, and can significantly reduce the postoperative complications, which is worthy of clinical promotion.