NOX-1基因及其在恶性肿瘤中的作用和分子机制

doi:10.3969/j.issn.2095-378X.2017.04.014

摘要/Abstract

摘要： NADPH氧化酶-1(NADPH oxidase-1,NOX-1)是NADPH氧化酶(nicotinamide adenine dinucleotide phosphate oxidase,NADPH oxidase,NOX)家族成员之一。NOX是调节体内氧化还原反应的关键酶,也是最早被确认的产生活性氧类(reactive oxygen species,ROS)的体系。一方面,少量的ROS可增强免疫防御,参与细胞分化、增殖、凋亡及细胞间信号通路的调控;另一方面,过多的ROS可引起氧化应激,致使细胞生理功能紊乱,对加速炎症、纤维化和肿瘤形成等病理过程起着重要作用。作为ROS主要来源之一,NOX-1在肿瘤形成过程中扮演重要角色。本文综述NOX-1及其在肿瘤中的作用和分子机制研究进展,以期探寻胆囊癌等恶性肿瘤诊治和预后判断的有效靶标。

关键词: NADPH氧化酶-1, 活性氧类, 肿瘤, 胆囊癌

Abstract: NADPH oxidase-1 (NOX-1) is a member of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase,NOX) family.NOX is the key enzyme that regulates oxidation-reduction reaction in vivo and the earliest known system for producing reactive oxygen species (ROS).On the one hand,a small amount of ROS can enhance immune defense and participate in the regulation of cell differentiation,proliferation,apoptosis,and intercellular signaling pathways.On the other hand,excessive ROS can cause oxidative stress,resulting in cell physiological dysfunction,and play an important role in accelerating the pathogenesis of inflammation,fibrosis,and tumor formation.As one of the main sources of ROS,NOX-1 plays an important role in tumor formation.This paper reviewed NOX-1 and its roles and molecular mechanisms in tumors,in order to explore the effective targets for diagnosis and prognosis of malignant tumors such as gallbladder cancer.

Key words: NADPH oxidase-1, Reactive oxygen species, Neoplasm, Gallbladder cancer

中图分类号:

R735.8

徐国利, 范跃祖. NOX-1基因及其在恶性肿瘤中的作用和分子机制[J]. 外科研究与新技术, 2017, 6(4): 276-280.

XU Guoli, FAN Yuezu. NOX-1 gene and its roles and molecular mechanisms in malignant tumors[J]. Surgical Research and New Technique, 2017, 6(4): 276-280.

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