轻型颅脑损伤后患者血清生物标志物GFAP-BPDs的相关性研究

外科研究与新技术 ›› 2014, Vol. 3 ›› Issue (1): 24-27.

轻型颅脑损伤后患者血清生物标志物GFAP-BPDs的相关性研究

薛龙¹, 尧荣凤², 葛岭¹, 黄晓伟¹, 陈洁波¹

1.同济大学附属杨浦医院神经外科上海 200090; 2.同济大学附属杨浦医院检验科上海 200090

出版日期:2014-03-28 发布日期:2014-01-25
作者简介:薛龙(1981-),男,研究生,从事脑外伤及其生物标志物方面的研究。

The relationship between mild traumatic brain injury (mTBI) and serum glial fibrillary acidic protein breakdown products (GFAP-BDPs ) change

XUE Long¹, YAO Rong-feng², GE Ling¹, HUANG Xiao-wei¹, CHEN Jie-bo¹

1.Neurosurgery,Yangpu Hospital of Shanghai Tongji university,Shanghai 200090,China;
2.Clinical Laboratory,Yangpu Hospital of Shanghai Tongji university,Shanghai 200090,China

Online:2014-03-28 Published:2014-01-25

摘要/Abstract

摘要： 目的探讨轻型颅脑损伤(mild traumatic brain injury,mTBI)后患者血清胶质细胞纤维酸性蛋白分解产物(glial fibrillary acidic protein breakdown products ,GFAP-BDPs)含量的临床意义和患者预后关系。方法用ELISA 法检测47例轻型颅脑损伤患者血清GFAP-BDPs含量并与20例体检健康患者比较。对比27例头颅CT阴性和20例头颅CT阳性mTBI患者血清GFAP-BDPs含量。评估患者6个月后GOS-E评分和mTBI患者血清GFAP-BDPs含量的关系。结果轻型颅脑损伤患者血清GFAP-BDPs含量高于正常对照组(P<0.05)。结论血清GFAP-BDPs可作为轻型颅脑损伤诊断的生物标志物,对鉴别mTBI患者后头颅CT阳性和阴性患者有一定准确性,血清GFAP-BDPs含量越高患者预后越差。

关键词: GFAP-BDPs, 轻型颅脑损伤, GOS-E

Abstract: Objective To explore the relationship of clinical significance and prognosis between patients with mild traumatic brain injury (mTBI) and glial fibrillary acidic protein breakdown products(GFAP-BDPs) change.Methods Detected by ELISA in 47 cases of mild head injury patients and 20 healthy subjects serum GFAP-BDPs content,and the Results were compared.Comparison the serum concentrations of GFAP-BDPs between the 27 cases of head CT negative mTBI patients and the 20 cases of head CT positive mTBI patients.The relationship was assessed between the GOS-E score of mTBI patient after 6 months and the concentrations of GFAP-BDPs in the serum of patients.Results Serum of patients with mild head injury GFAP-BDPs were significantly higher than that of the control group (P<0.05).Conclusion GFAP-BDPs serum can be used as diagnostic biomarkers of mTBI,It has a certain accuracy that serum GFAP-BDPs levels can identify patients with positive and negative head CT; The higher levels of serum GFAP-BDPs worse prognosis.

Key words: GFAP-BDPs, mTBI, GOS-E

中图分类号:

R642

薛龙, 尧荣凤, 葛岭, 黄晓伟, 陈洁波. 轻型颅脑损伤后患者血清生物标志物GFAP-BPDs的相关性研究[J]. 外科研究与新技术, 2014, 3(1): 24-27.

XUE Long, YAO Rong-feng, GE Ling, HUANG Xiao-wei, CHEN Jie-bo. The relationship between mild traumatic brain injury (mTBI) and serum glial fibrillary acidic protein breakdown products (GFAP-BDPs ) change[J]. Surgical Research and New Technique, 2014, 3(1): 24-27.

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