肿瘤淋巴转移和淋巴管生成研究

外科研究与新技术 ›› 2014, Vol. 3 ›› Issue (1): 50-54.

肿瘤淋巴转移和淋巴管生成研究

李洁静¹(综述), 庄志刚¹, 范跃祖²(审校)

1.同济大学附属上海市第一妇婴保健院乳腺外科上海 200092;
2.同济大学附属同济医院普外科上海 200065

出版日期:2014-03-28 发布日期:2014-01-25
通讯作者: 范跃祖(1958-),男,外科学教授、博导,研究胆胰消化肿瘤外科治疗及其相关基础研究,E-mail:fanyuezu@hotmail.com
作者简介:李洁静(1988-),女,同济大学医学院在读研究生。
基金资助:
上海市卫生局项目(20124164),上海市科委医学引导类项目(124119a4700)

Research on lymphatic metastasis and lymphangiogenesis in tumor

LI Jie-jing¹, ZHUANG Zhi-gang¹, FAN Yue-zu²

1.Department of Breast Surgery,Shanghai First Maternity and Infant Hospital,Tongji University School of Medicine,Shanghai 200092,China;
2.Department of Surgery,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,China

Online:2014-03-28 Published:2014-01-25

摘要/Abstract

摘要： 随着多个促淋巴管生成因子和淋巴管内皮细胞标记物如血管内皮生长因子-C/D、透明质酸、果蝇prospero同源转录因子、血管内皮生长因子受体-3、肾小球足突细胞膜蛋白、淋巴管内皮细胞透明质酸受体-1以及肿瘤胚胎性抗原M2A的单克隆抗体等的发现,有关肿瘤淋巴转移和淋巴管生成的研究得到了重视。目前,肿瘤淋巴转移和淋巴管生成及其机制研究已成为肿瘤研究的热点。该文对近期发现的促淋巴因子和淋巴管内皮细胞标记物进行简要综述,为恶性肿瘤的检出、诊断与治疗提供新的思路与靶点。

关键词: 淋巴转移, 淋巴管生成, 促淋巴管生成因子, 淋巴管内皮细胞标记物

Abstract: With multiple growth factors of promoting lymphangiogenesis and lymphatic endothelial cell markers such as vascular endothelial growth factor-C/D,hyaluronic acid,prospero related homeobox gene-1,vascular endothelial growth factor receptor-3,podoplanin,1ymphatic vessel endothelial hyaluronan receptor-1 and D2-40 were found,more attention was paid to study on lymphatic metastasis and lymphangiogenesis in tumor.Currently,the study on lymphatic metastasis and lymphangiogenesis in tumor and its mechanism has become a new hot topic of cancer research.This paper is a brief review of recently discovered growth factors of promoting lymphangiogenesis and lymphatic endothelial cell markers,providing new ideas and targets for detection,diagnosis and treatment of malignant tumors.

Key words: Lymphatic metastasis, Lymphangiogenesis, Growth factors of promoting lymphangiogenesis, Lymphatic endothelial cell markers

中图分类号:

R730

李洁静(综述), 庄志刚, 范跃祖(审校). 肿瘤淋巴转移和淋巴管生成研究[J]. 外科研究与新技术, 2014, 3(1): 50-54.

LI Jie-jing, ZHUANG Zhi-gang, FAN Yue-zu. Research on lymphatic metastasis and lymphangiogenesis in tumor[J]. Surgical Research and New Technique, 2014, 3(1): 50-54.

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