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外科研究与新技术（中英文）

外科研究与新技术 ›› 2016, Vol. 5 ›› Issue (1): 4-6.

• 论著 • 上一篇    下一篇

血清T、DHT表达水平差异在BPH、PCa患者人群中的初步临床研究

孟凯1,吴登龙2,乐威2   

  1. 1. 上海同济大学附属同济医院
    2. 同济大学附属同济医院
  • 收稿日期:2016-01-05 修回日期:2016-02-17 出版日期:2016-03-28 发布日期:2016-03-08
  • 通讯作者: 吴登龙 E-mail:wudenglong2013@126.com

A preliminary study of the T、DHT level variant between BPH and PCa patients : A case confed study

  • Received:2016-01-05 Revised:2016-02-17 Online:2016-03-28 Published:2016-03-08

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摘要： 目的：通过研究良性前列腺增生与前列腺癌患者血清睾酮、双氢睾酮水平及睾酮/双氢睾酮比值的差异变化，探索T/DHT在前列腺癌诊疗中的应用。方法：收集2015年1月—2015年6月115例良性前列腺增生和81例前列腺癌患者血清，分析血清总睾酮（T）、双氢睾酮（DHT）水平及睾酮（T）/双氢睾酮（DHT）在BPH及PCa患者人群中表达水平差异，初步评估二者血清总睾酮（T）、双氢睾酮（DHT）水平比较差异，进而探求睾酮（T）/双氢睾酮（DHT）比值水平变化对PCa诊疗的意义。结果：前列腺癌患者较良性前列腺增生患者血清总睾酮（T）、双氢睾酮（DHT）水平及睾酮（T）/双氢睾酮（DHT）比值明显减低，比较差异有统计学意义（p<0.05）。结论：监测患者T/DHT比值水平变化对前列腺癌诊疗可能有一定意义。

关键词: 前列腺增生, 前列腺癌, 睾酮, 双氢睾酮, 睾酮/双氢睾酮

Abstract: Objective To explore the application of T/DHT in Prostate Cancer（PCa） through estimating the difference of serum total T、DHT level and ratio of T/ DHT between Benign Prostatic Hyperplasia（BPH） and Prostate Cancer（PCa）. Methods 196 cases were included in the study including 115 of BPH and 81 of PCa patients from January 2015 to June 2015. The differences of serum total T、DHT level and ratio of T/DHT between two groups were studied and analyzed to investigate the significance of T/DHT in diagnosis and treatment of PCa. Results The level of serum total T、DHT and the ratio of T/DHT were lower in BPH group than PCa group. The difference was statistically significant (p< 0.05). Conclusions T、DHT level and ratio of T/DHT may play a important role in diagnosis and treatment of PCa.

Key words: Benign prostatic hyperplasia, prostate cancer, testosterone (T), dihydrotestosterone (DHT), testosterone (T)/dihydrotestosterone (DHT)