关键词: 阿尔茨海默病, 生物信息学, 发病机制, 药物设计

Abstract: Alzheimer's disease (AD) is a common neurodegenerative disease, the main clinical manifestations of it is progressive memory impairment and cognitive dysfunction. However, the molecular pathogenesis of AD is complex and unclear, is the result of various genes and cellular signaling pathway interactions. Lacking the effective treatment of AD clinically, AD has become difficulty neuroscience clinical treatment. Currently, bioinformatics in medicine is widely applied. Using it to analysis the related gene chip data, construct the related gene and cell signal transduction pathway network diagram of AD, can systematic analysis pathogenesis of AD and screen the key signaling pathway, gene and enzyme, which will provide a new perspective of the drug design and re-use and a new theoretical basis to treat AD.

Key words: Alzheimer's disease, bioinformatics, pathogenesis, drug design